Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques

Kent, Stephen J., De Rose, Robert, Mokhonov, Vlad V., Mokhonova, Ekaterina I., Fernandez, Caroline S., Alcantara, Sheilajen, Rollman, Erik, Mason, Rosemarie D., Loh, Liyen, Peut, Viv, Reece, Jeanette C., Wang, Xiang Ju, Wilson, Kim M., Suhrbier, Andreas and Khromykh, Alexander (2008) Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques. Virology, 374 2: 528-534. doi:10.1016/j.virol.2008.01.006


Author Kent, Stephen J.
De Rose, Robert
Mokhonov, Vlad V.
Mokhonova, Ekaterina I.
Fernandez, Caroline S.
Alcantara, Sheilajen
Rollman, Erik
Mason, Rosemarie D.
Loh, Liyen
Peut, Viv
Reece, Jeanette C.
Wang, Xiang Ju
Wilson, Kim M.
Suhrbier, Andreas
Khromykh, Alexander
Title Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
1089-862X
1096-0341
Publication date 2008-05-10
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.virol.2008.01.006
Open Access Status DOI
Volume 374
Issue 2
Start page 528
End page 534
Total pages 7
Place of publication San Diego, CA
Publisher Academic Press
Language eng
Subject C1
060502 Infectious Agents
060506 Virology
110802 Medical Infection Agents (incl. Prions)
110804 Medical Virology
110309 Infectious Diseases
920109 Infectious Diseases
920412 Preventive Medicine
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract Persistent gag-specific T cell immunity would be a useful component of an effective HIV vaccine. The Flavivirus Kunjin replicon was previously engineered to persistently express HIV gag and was shown to induce protective responses in mice. We evaluated Kunjin replicon virus-like-particles expressing SIVgag–pol in pigtail macaques. Kunjin-specific antibodies were induced, but no SIV-specific T cell immunity were detected. Following SIVmac251 challenge, there was no difference in SIV viremia or retention of CD4 T cells between Kunjin–SIVgag–pol vaccine immunized animals and controls. An amnestic SIV gag-specific CD8 T cell response associated with control of viremia was observed in 1 of 6 immunized animals. Refinements of this vector system and optimization of the immunization doses, routes, and schedules are required prior to clinical trials.
Keyword Kunjin
HIV
SIV
Macaques
Macaca nemestrina
Vaccines
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 20 Mar 2009, 22:35:57 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences