Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste

Francis, Stephen P., Baade, Lisa M., Kubofoik, Joseph, Nutman, Thomas B., Melrose, Wayne D., McCarthy, James S. and Nissen, Michael D. (2008) Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste. The American Journal of Tropical Medicine and Hygiene, 78 4: 560-563.

Author Francis, Stephen P.
Baade, Lisa M.
Kubofoik, Joseph
Nutman, Thomas B.
Melrose, Wayne D.
McCarthy, James S.
Nissen, Michael D.
Title Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste
Journal name The American Journal of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0002-9637
Publication date 2008-04-01
Year available 2008
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 78
Issue 4
Start page 560
End page 563
Total pages 4
Editor J. W. Kazura
Place of publication McLean, VA., USA
Publisher The American Society of Tropical Medicine and Hygiene
Language eng
Subject 060502 Infectious Agents
060506 Virology
810102 Army
920109 Infectious Diseases
Abstract To investigate whether Australian soldiers were exposed to filarial parasites that cause lymphatic filariasis during a 6-month deployment to Timor-Leste, antifilarial antibody levels were measured in 907 soldiers using an enzyme linked immunosorbent assay (ELISA). Initial testing using Dirofilaria immitis antigen demonstrated that 49 of 907 (5.4%) soldiers developed antifilarial antibodies of the IgG1 subclass after deployment, whereas 1 of 944 (0.1%) seroconverted to the IgG4 subclass. When a sub sample of 88 D. immitis-reactive sera was subject to testing with an antifilarial antibody test using Brugia malayi antigen, 46 had elevated IgG antibodies, whereas 5 had elevated antibodies of the IgG4 subclass. A total of 24 soldiers seroconverted to B. malayi, as measured by parasite-specific IgG, whereas 1 seroconverted to IgG4. The relatively low number of seroconversions indicates a low but measurable risk of exposure to human filarial parasites among Australian soldiers deployed to Timor-Leste. However, to reduce the risk of exposure to these parasites, soldiers deploying to endemic areas should practice strict adherence to personal protective measures against mosquito bites.
Keyword Seroconversion
filarial antigens
filarial parasites
lymphatic filariasis
Enzyme-linked Immunosorbent Assay
Dirofilaria immitis antigen
brugia malayi antigen
personal protective measures
mosquito bites
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Clinical Medical Virology Centre Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 20 Mar 2009, 21:54:14 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre