A 5- verus 3- day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomized control trial

Chang, Anne B., Clark , Ronald, Sloots, Theo P., Stone, David G., Petsky, Helen L., Thearle, Donna, Champion, Anita A., Wheeler, Coralie and Acworth, Jason P. (2008) A 5- verus 3- day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomized control trial. Medical Journal of Australia, 189 6: 306-310.


Author Chang, Anne B.
Clark , Ronald
Sloots, Theo P.
Stone, David G.
Petsky, Helen L.
Thearle, Donna
Champion, Anita A.
Wheeler, Coralie
Acworth, Jason P.
Title A 5- verus 3- day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomized control trial
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2008-09-15
Year available 2008
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 189
Issue 6
Start page 306
End page 310
Total pages 5
Editor M. Van Der Weyden
Place of publication Australia
Publisher Australian Medical Publishing Company Pty Ltd
Language eng
Subject 060506 Virology
920115 Respiratory System and Diseases (incl. Asthma)
920501 Child Health
C1
Abstract Objective: To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised.
Formatted abstract
Objective:

To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised.

Design, setting and participants:

Double-blind randomised controlled trial of asthma outcomes following a 5-day course of oral prednisolone (1 mg/kg) compared with a 3-day course of prednisolone plus placebo for 2 days. Participants were children aged 2–15 years who presented to the emergency departments of three Queensland hospitals between March 2004 and February 2007 with an acute exacerbation of asthma, but were not hospitalised. Sample size was defined a priori for a study power of 90%.

Main outcome measures:


Difference in proportion of children who were symptom-free at Day 7, as measured by intention-to-treat (ITT) and per-protocol analysis; quality of life (QOL) on Days 7 and 14.
Results:

201 children were enrolled, and there was an 82% completion rate. There was no difference between groups in the proportion of children who were symptom-free (observed difference, 0.04 [95% CI, − 0.09 to 0.18] by ITT analysis; 0.04 [95% CI, − 0.17 to 0.09] by per-protocol analysis). There was also no difference between groups in QOL (P = 0.42). The difference between groups for the primary outcome was within the equivalence range calculated post priori.

Conclusion:


A 5-day course of oral prednisolone confers no advantage over a 3-day course for children with asthma exacerbations who are not hospitalised.



Australian Clinical Trials Registry ACTRN012605000305628.

Keyword asthma
oral corticosteroids
asthma exacerbations
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Can not locate a doi.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 20 Mar 2009, 21:10:31 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre