Risk factors for oral mucositis in children undergoing chemotherapy: A matched case-control study

Cheng, Karis K. F., Goggins, William B., Lee, Vincent W. S. and Thompson, David R. (2008) Risk factors for oral mucositis in children undergoing chemotherapy: A matched case-control study. Oral Oncology, 44 11: 1019-1025. doi:10.1016/j.oraloncology.2008.01.003

Author Cheng, Karis K. F.
Goggins, William B.
Lee, Vincent W. S.
Thompson, David R.
Title Risk factors for oral mucositis in children undergoing chemotherapy: A matched case-control study
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
Publication date 2008-11-01
Sub-type Article (original research)
DOI 10.1016/j.oraloncology.2008.01.003
Open Access Status Not yet assessed
Volume 44
Issue 11
Start page 1019
End page 1025
Total pages 7
Editor Crispian Scully
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1110 Nursing
920501 Child Health
920102 Cancer and Related Disorders
111208 Radiation Therapy
1112 Oncology and Carcinogenesis
Formatted abstract
Oral mucositis (OM) is the most frequent and severe complication of chemotherapy for children with cancer, yet little is known about its risk factors. The aim of this study was to determine the risk factors associated with chemotherapy-induced OM in children. A matched case-control design was used. The matching criteria were age, type of cancer and chemotherapy regimen. Patient-and treatment-related data were collected via chart review. Conditional logistic regression analyses were performed to estimate odds ratios (OR) and adjusted odds ratios (AOR) for the development of OM. Fifty-one cases and 51 controls were identified. The mean ± SD age of the children was 7.6 ± 5.2 years, with 65 (63.73%) boys. Eighty-two percent of the children had been diagnosed with haematological malignancies (n = 84). The most common chemotherapy regimen was a combination of plant alkaloids and antitumor antibiotics (n = 42, 41.18%). In the multivariable model, lower body weight (AOR = 0.91; 95% CI = 0.84–0.98; p = 0.013), lower value of log nadir neutrophil count (AOR = 0.33; 95% CI = 0.16–0.68; p = 0.0025), and higher value of peak creatinine (AOR = 1.06; 95% CI = 1.01–1.12; p = 0.025) were significantly associated with a greater risk of OM. Our findings suggest that children who are neutropenic, those with serum creatinine elevation, and those with a low body weight prior to chemotherapy are at greater risk of developing OM.
© 2008 Elsevier Ltd. All rights reserved.
Keyword Oral mucositis
Paediatric patients
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code

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