Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: Platelet dynamics and perinatal outcome

Overton, Timothy G., Duncan, Keith R., Jolly, Matthew, Letsky, Elizabeth and Fisk, Nicholas M. (2002) Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: Platelet dynamics and perinatal outcome. American Journal of Obstetrics and Gynecology, 186 4: 826-831. doi:10.1067/mob.2002.122140


Author Overton, Timothy G.
Duncan, Keith R.
Jolly, Matthew
Letsky, Elizabeth
Fisk, Nicholas M.
Title Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: Platelet dynamics and perinatal outcome
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 2002-04-01
Year available 2002
Sub-type Article (original research)
DOI 10.1067/mob.2002.122140
Open Access Status
Volume 186
Issue 4
Start page 826
End page 831
Total pages 6
Editor T. J. Garite
M. H. Kim
Place of publication St Louis, MO, U.S.A.
Publisher Mosby
Language eng
Subject 111402 Obstetrics and Gynaecology
Abstract OBJECTIVES: Our purpose was to describe the fetal loss rate and platelet dynamics in fetal alloimmune thrombocytopenia managed by serial platelet transfusions.
Formatted abstract
Objectives: Our purpose was to describe the fetal loss rate and previous termplateletnext term dynamics in fetal alloimmune thrombocytopenia managed by serial previous termplateletnext term transfusions.
Methods: Retrospective analysis over 10 years of consecutive pregnancies affected by fetal alloimmune thrombocytopenia requiring in utero previous termplateletnext term transfusions.
Results: There were 2 perinatal losses in 12 pregnancies managed by 84 previous termplateletnext term transfusions. One was obviously procedure related from exsanguination despite previous termplateletnext term transfusion. The attributable procedurerelated fetal loss rate was 1.2% per procedure but 8.3% per pregnancy. The median rate of fall in fetal previous termplateletnext term count per day after transfusion was lower at the placental cord insertion (n = 54) 40.5 × 109/L (range, 5.4-96.1 × 109/L) compared with that at the intrahepatic vein (n = 30) 50.9 × 109/L,(range, 29.5-91 × 109/L) (P = .0009).
Conclusion: Pooling our results with those previously published yields a cumulative risk of serial weekly transfusions of approximately 6% per pregnancy, indicating the need for development of less invasive approaches.
Copyright © 2002 Mosby, Inc. All rights reserved.

Keyword Platelets
Transfusion
Fetal
Alloimmune
Thrombocytopenia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 20 Mar 2009, 00:26:55 EST by Maria Campbell on behalf of Faculty Of Health Sciences