Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children

Alati, Rosa, MacLeod.,John, Hickman, Matthew, Sayal, Kapil, May, Margaret, Davey-Smith, George and Lawlor, Debbie (2008) Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children. Pediatric Research, 64 6: 659-666. doi:10.1203/PDR.0b013e318187cc31


Author Alati, Rosa
MacLeod.,John
Hickman, Matthew
Sayal, Kapil
May, Margaret
Davey-Smith, George
Lawlor, Debbie
Title Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 2008-12-01
Year available 2008
Sub-type Article (original research)
DOI 10.1203/PDR.0b013e318187cc31
Open Access Status Not Open Access
Volume 64
Issue 6
Start page 659
End page 666
Total pages 8
Editor Devaskar, Sherin U
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
111706 Epidemiology
920414 Substance Abuse
Abstract This study aims to test the hypothesis that moderate maternal alcohol and tobacco use in pregnancy is associated with intelligent quotient (IQ) scores in childhood through intrauterine mechanisms. We conducted parental-offspring comparisons between the associations of tobacco and alcohol consumption with child's IQ in the Avon Longitudinal Study of Parents and Children. Analyses were conducted on 4332 participants with complete data on maternal and paternal use of alcohol and tobacco at 18 wk gestation, child's IQ and a range of confounders. IQ was measured at child age 8 with the Weschler Intelligence Scale for Children (WISC-III). We used multivariable linear and logistic regression to estimate mean differences and 95% confidence intervals in IQ scores across the exposure categories and computed f statistics to compare maternal and paternal associations. In fully adjusted models, there was no strong statistical evidence that maternal alcohol and tobacco consumption during pregnancy were associated with childhood IQ with any greater magnitude than paternal alcohol and tobacco consumption (also assessed during their partners' pregnancy). Our findings suggest that the relationship between maternal moderate alcohol and tobacco use in early pregnancy and childhood IQ may not be explained by intrauterine mechanisms.
Keyword Pediatrics
Pediatrics
PEDIATRICS
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID G0600705
G9815508
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Public Health Publications
 
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Created: Fri, 20 Mar 2009, 00:18:13 EST by Yvonne Flanagan on behalf of School of Public Health