CD34+ cells from first-trimester fetal blood are enriched in primitive hemopoietic progenitors

Tocci, Angelo, Roberts, Irene A. G., Kumar, Sailesh, Bennett, Phillip R. and Fisk, Nicholas M. (2003) CD34+ cells from first-trimester fetal blood are enriched in primitive hemopoietic progenitors. American Journal of Obstetrics and Gynecology, 188 4: 1002-1010. doi:10.1067/mob.2003.236


Author Tocci, Angelo
Roberts, Irene A. G.
Kumar, Sailesh
Bennett, Phillip R.
Fisk, Nicholas M.
Title CD34+ cells from first-trimester fetal blood are enriched in primitive hemopoietic progenitors
Formatted title
CD34+ cells from first-trimester fetal blood are enriched in primitive hemopoietic progenitors


Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 2003-04-01
Year available 2003
Sub-type Article (original research)
DOI 10.1067/mob.2003.236
Open Access Status
Volume 188
Issue 4
Start page 1002
End page 1010
Total pages 9
Place of publication St. Louis, MO, U.S.A.
Publisher Mosby
Language eng
Subject 111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Abstract OBJECTIVE: The purpose of this study was to investigate whether purified CD34(+) cells from first-trimester fetal blood are a source of primitive and committed hemopoietic progenitors.
Formatted abstract
Objective: The purpose of this study was to investigate whether purified CD34+ cells from first-trimester fetal blood are a source of primitive and committed hemopoietic progenitors.
Study Design: CD34+ cells from first-trimester fetal blood and term cord blood were assayed for committed hemopoietic progenitor cells, high proliferative potential colony-forming cells, and long-term cultureinitiating cells.
Results: First-trimester CD34+ cells that were compared with cells at term generated fewer hemopoietic progenitor cells and fewer high proliferative potential colony-forming cells with lower recloning efficiency (P < .001). First-trimester CD34+ cells tended to contain more long-term culture-initiating cells, both in bulk cultures and by limiting dilution analysis. The ratio between committed and primitive progenitors was 3 in the first-trimester and 20 in the term cord blood, respectively.
Conclusion: First-trimester fetal blood is enriched in primitive (compared with committed) hemopoietic progenitors and may be an advantageous source of stem cells for prenatal therapy.
Copyright © 2003 Mosby, Inc. All rights reserved.

Keyword Hemopoietic progenitors
Gene therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 19 Mar 2009, 22:43:46 EST by Mary-Anne Marrington on behalf of Faculty Of Health Sciences