Kidneys from patients with small renal tumours: A novel source of kidneys for transplantation

Nicol, David L., Preston, John M., Wall, Daryl R., Griffin, Anthony D., Campbell, Scott B., Isbel, Nicole M., Hawley, Carmel M. and Johnson, David W. (2008) Kidneys from patients with small renal tumours: A novel source of kidneys for transplantation. BJU International, 102 2: 188-193. doi:10.1111/j.1464-410X.2008.07562.x

Author Nicol, David L.
Preston, John M.
Wall, Daryl R.
Griffin, Anthony D.
Campbell, Scott B.
Isbel, Nicole M.
Hawley, Carmel M.
Johnson, David W.
Title Kidneys from patients with small renal tumours: A novel source of kidneys for transplantation
Journal name BJU International   Check publisher's open access policy
ISSN 1464-4096
Publication date 2008-07-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1464-410X.2008.07562.x
Open Access Status DOI
Volume 102
Issue 2
Start page 188
End page 193
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject C1
920118 Surgical Methods and Procedures
110312 Nephrology and Urology
Formatted abstract
To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant.
Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally detected tumours. After bench surgery to excise the tumour, they were all successfully transplanted into patients who were elderly or had significant comorbidities.
Apart from four patients who died from unrelated illnesses, all grafts continued to function with a median and mean follow-up of 25 and 32 months. The follow-up, which included 3-monthly renal ultrasonography and chest X-rays, showed only one case of tumour recurrence, which occurred 9 years after transplantation; the patient remains stable under observation after 18 months.
From our experience we consider that where nephrectomy is used for small, localized, incidentally detected renal tumours, the kidney should be considered for transplantation into carefully selected patients. Such patients with numerous medical comorbidities might benefit from renal transplantation, but not survive the waiting period if they are dependent on a deceased donor graft. Paradoxically the use of these marginal kidneys has the potential to increase the quality and length of life of these patients, despite the apparent contradiction of an intuitive principle of organ transplantation and immunosuppression.
Keyword Renal tumours
Live donors
Renal transplantation
Novel donor source
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published Online: 28 Jun 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 19 Mar 2009, 22:32:06 EST by Denise Wilson on behalf of School of Medicine