Fetal stem cells : betwixt and between

Guillot, Pascale V, O'Donoghue, Keelin, Kurata, Hitoshi and Fisk, Nicholas M. (2006) Fetal stem cells : betwixt and between. Seminars in Reproductive Medicine, 24 5: 340-347. doi:10.1055/s-2006-952149


Author Guillot, Pascale V
O'Donoghue, Keelin
Kurata, Hitoshi
Fisk, Nicholas M.
Title Fetal stem cells : betwixt and between
Journal name Seminars in Reproductive Medicine   Check publisher's open access policy
ISSN 1526-8004
Publication date 2006-11-01
Year available 2006
Sub-type Article (original research)
DOI 10.1055/s-2006-952149
Open Access Status
Volume 24
Issue 5
Start page 340
End page 347
Total pages 8
Editor J. Itskovtitz-Eldor
Place of publication NEW YORK
Publisher Thieme Medical Publishers
Language eng
Subject 111401 Foetal Development and Medicine
111402 Obstetrics and Gynaecology
Abstract Fetal stem cells can be isolated not only from fetal blood and hemopoietic organs in early pregnancy, but from a variety of somatic organs as well as amniotic fluid and placenta throughout gestation. Fetal blood is a rich source of hemopoietic stem cells, which proliferate more rapidly than those in cord blood or adult bone marrow. First-trimester fetal blood, liver, and bone marrow also contain a population of mesenchymal stem cells, which appear to be more primitive with greater multipotentiality than their adult counterparts. Fetal stem cells may thus represent an intermediate cell type in the current debate focusing on dichotomized adult versus embryonic stem cells, and thus prove advantageous as a source for downstream cell therapy applications. They have also been implicated in fetomaternal trafficking in pregnancy, and in long-term microchimerism in postreproductive women.
Keyword Fetal tissue
fetal and cord blood
mesenchymal stem cell
hemopoietic stem cell
fetal therapy
fetomaternal microchimerism
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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