Continuous measurement of cerebral blood flow velocity using transcranial Doppler reveals significant moment-to-moment variability of data in healthy volunteers and in patients with subarachnoid hemorrhage

Venkatesh, Bala, Shen, Qiaomei and Lipman, Jeffrey (2002) Continuous measurement of cerebral blood flow velocity using transcranial Doppler reveals significant moment-to-moment variability of data in healthy volunteers and in patients with subarachnoid hemorrhage. Critical Care Medicine, 30 3: 563-569. doi:10.1097/00003246-200203000-00011


Author Venkatesh, Bala
Shen, Qiaomei
Lipman, Jeffrey
Title Continuous measurement of cerebral blood flow velocity using transcranial Doppler reveals significant moment-to-moment variability of data in healthy volunteers and in patients with subarachnoid hemorrhage
Journal name Critical Care Medicine   Check publisher's open access policy
ISSN 0090-3493
Publication date 2002-03-01
Sub-type Article (original research)
DOI 10.1097/00003246-200203000-00011
Open Access Status
Volume 30
Issue 3
Start page 563
End page 569
Total pages 7
Place of publication Maryland
Publisher Lippincott Williams & Wilkins
Language eng
Subject 110310 Intensive Care
Abstract Objective: The reliability of intermittent transcranial Doppler has not been accepted widely because of problems with interobserver variability and lack of accuracy. The limitations of intermittent transcranial Doppler are thought to be overcome by continuous measurement systems. However, little published data exist on their accuracy, feasibility, and moment-to-moment variability. In this study we aimed to determine the time-related variability of continuous transcranial Doppler signal from volunteers and patients with subarachnoid hemorrhage and to examine the feasibility, ease of use, and quality of data generated from continuous transcranial Doppler for the detection of vasospasm. Design: Prospective observational study. Setting: Intensive care unit in a tertiary referral center. Subjects: Ten volunteers and eight patients with aneurysmal subarachnoid hemorrhage. Interventions: None. Measurements and Main Results: The middle cerebral artery blood flow velocities were recorded continuously from both patients and volunteers. The moment-to-moment variability of continuously recorded data was calculated. There was a wide range of velocity measurements in both volunteers and patients. There was a significant moment-to-moment variability in both volunteers (−31% to 58%) and in patients (−38% to 78%). There was a greater number of observations exceeding 10% moment-to-moment variability in the patient group with regard to systolic and diastolic velocities compared with volunteers (8% vs. 2%, p < .001). There was a trend toward a longer duration of good quality data in volunteers compared with patients (98 ± 0.5% vs. 96 ± 9%). Conclusions: Continuous measurement of cerebral blood flow velocities revealed a significant moment-to-moment variability in both patients and in volunteers, the magnitude of which was greater in the patients. The clinical implications of these findings are discussed.
Keyword Medical emergencies
accuracy
aneurysm
blood flow
cerebral
Doppler
subarachnoid hemorrhage
transcranial
variability
vasospasm
velocity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 19 Mar 2009, 21:43:23 EST by Ms Karen Naughton on behalf of Anaesthesiology and Critical Care - RBWH