Genital lentigines and melanocytic nevi with superimposed lichen sclerosus: A diagnostic challenge

Shabrawi-Caelen, Laila E. l., Soyer, H. Peter, Schaeppi, Herwig, Cerroni, Lorenzo, Schirren, Carl G., Rudolph, Christina and Kerl, Helmut (2004) Genital lentigines and melanocytic nevi with superimposed lichen sclerosus: A diagnostic challenge. Journal of the American Academy of Dermatology, 50 5: 690-694. doi:10.1016/j.jaad.2003.09.034


Author Shabrawi-Caelen, Laila E. l.
Soyer, H. Peter
Schaeppi, Herwig
Cerroni, Lorenzo
Schirren, Carl G.
Rudolph, Christina
Kerl, Helmut
Title Genital lentigines and melanocytic nevi with superimposed lichen sclerosus: A diagnostic challenge
Journal name Journal of the American Academy of Dermatology   Check publisher's open access policy
ISSN 0190-9622
Publication date 2004-05-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.jaad.2003.09.034
Open Access Status
Volume 50
Issue 5
Start page 690
End page 694
Total pages 5
Place of publication New York, U.S.A.
Publisher Elsevier
Language eng
Subject 110304 Dermatology
Abstract Background: Benign pigmented lesions of the genitalia, such as genital lentigines and melanocytic nevi, often show clinical and histopathologic features highly suggestive of malignant melanoma (MM). Superimposed changes of lichen sclerosus (LS) may cause real concern and lead to an erroneous diagnosis of MM.
Formatted abstract
Background: Benign pigmented lesions of the genitalia, such as genital lentigines and melanocytic nevi, often show clinical and histopathologic features highly suggestive of malignant melanoma (MM). Superimposed changes of lichen sclerosus (LS) may cause real concern and lead to an erroneous diagnosis of MM.
Objective: This study was performed to assess clinicopathologic characteristics of genital lentigines and melanocytic nevi with associated LS.
Methods: We performed a retrospective review of 5 cases.
Results: Histopathologic sections of the 2 cases of genital lentigines with concurrent changes of LS showed a lichenoid lymphocytic infiltrate and pigment incontinence with melanophages in a fibrosed papillary dermis, features reminiscent of completely regressed MM. The 3 cases of genital melanocytic nevi and superimposed LS were sharply circumscribed, relatively symmetric, but revealed confluent nests varying in size and shape and pagetoid upward spread of melanocytic nests and single melanocytes. Changes of LS extended beyond the melanocytic proliferation. Conclusion: Genital lentigines and melanocytic nevi with associated LS may show features that mimic MM.
Copyright © 2004 American Academy of Dermatology, Inc. Published by Mosby, Inc.

Keyword Dermatology
Genital lentigines
Melanocytic nevi
Malignant melanoma
Lichen sclerosus
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 19 Mar 2009, 19:47:57 EST by Ms Karen Naughton on behalf of School of Medicine