UV light–induced linear IgA dermatosis

Salmhofer, Wolfgang, Soyer, H. Peter, Wolf, Peter, Fodinger, Dagmar, Hodl, Stefan and Kerl, Helmut (2004) UV light–induced linear IgA dermatosis. Journal of the American Academy of Dermataology, 50 1: 109-115. doi:10.1016/S0190-9622(03)02120-0

Author Salmhofer, Wolfgang
Soyer, H. Peter
Wolf, Peter
Fodinger, Dagmar
Hodl, Stefan
Kerl, Helmut
Title UV light–induced linear IgA dermatosis
Journal name Journal of the American Academy of Dermataology   Check publisher's open access policy
ISSN 0190-9622
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/S0190-9622(03)02120-0
Open Access Status DOI
Volume 50
Issue 1
Start page 109
End page 115
Total pages 7
Editor Bruce H. Thiers
Place of publication Amsterdam, The Netherlands
Publisher American Academy of Dermataology
Language eng
Subject 110304 Dermatology
Abstract Various exogenous factors (eg, drugs, dietary antigens, trauma, infections, radiographs, and UV radiation) are known to induce or aggravate skin diseases. UV radiation in particular is known to induce or aggravate the autoimmune bullous diseases of pemphigus foliaceus, pemphigus vulgaris, and bullous pemphigoid. Its role in linear IgA dermatosis, however, is not well recognized. We report the second case of linear IgA dermatosis induced by intense sun exposure in which blistering was induced by UVA radiation. Furthermore, a review of the literature on photoinduced autoimmune bullous diseases and the wavelengths responsible for the induction of blistering is presented and several proposed mechanisms of action for the blister induction, including release or unmasking of antigens, promotion of antibody fixation by UV radiation, and launching of an inflammatory process, are discussed. We conclude that linear IgA dermatosis should be added to the list of autoimmune bullous diseases induced and/or aggravated by UV radiation.
Keyword UV radiation
Pemphigus foliaceus
Pemphigus vulgaris
Bullous pemphigoid
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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