Amelanotic/Hypomelanotic Melanoma – Is Dermatoscopy Useful For Diagnosis? : Amelanotisches/Hypopigmentiertes Melanom – Ist die Auflichtmikroskopie hilfreich für die Diagnose?

Zalaudek, I., Argenziano, G., Kerl, H., Soyer, H. P. and Hofmann-Wellenhof, R. (2003) Amelanotic/Hypomelanotic Melanoma – Is Dermatoscopy Useful For Diagnosis? : Amelanotisches/Hypopigmentiertes Melanom – Ist die Auflichtmikroskopie hilfreich für die Diagnose?. Journal der Deutschen Dermatologischen Gesellschaft; Journal of the German Society of Dermatology, 1 5: 369-373. doi:10.1046/j.1610-0387.2003.02042.x


Author Zalaudek, I.
Argenziano, G.
Kerl, H.
Soyer, H. P.
Hofmann-Wellenhof, R.
Title Amelanotic/Hypomelanotic Melanoma – Is Dermatoscopy Useful For Diagnosis? : Amelanotisches/Hypopigmentiertes Melanom – Ist die Auflichtmikroskopie hilfreich für die Diagnose?
Journal name Journal der Deutschen Dermatologischen Gesellschaft; Journal of the German Society of Dermatology   Check publisher's open access policy
ISSN 1610-0379
Publication date 2003-01-01
DOI 10.1046/j.1610-0387.2003.02042.x
Volume 1
Issue 5
Start page 369
End page 373
Total pages 5
Place of publication Berlin
Publisher Blackwell
Language eng
Subject 110304 Dermatology
Abstract Background: Amelanotic/hypomelanotic melanoma often leads to delayed clinical diagnosis because its clinical appearance can mimic other hypopigmented skin conditions. Dermatoscopy (dermoscopy, epiluminescence microscopy) is thought to be a helpful diagnostic tool in pigmented skin lesions, but it can be used also in non-pigmented skin tumors due to the recognition of vascular structures not visible to the naked eye. Objective: 7 amelanotic/hypomelanotic melanomas in 6 patients were analyzed in order to define their dermatoscopic findings using standard pattern analysis. Methods: Clinical and dermoscopic images of each lesion were obtained using Dermaphot (Heine Optotechnik, Herrsching, Germany), with 10-fold magnification of the lesion and the color slides were converted to digital format using a Kodak Photo CD system. Results: All 7 amelanotic/hypomelanotic melanomas revealed peculiar dermatoscopic findings, namely, atypical vessels, dotted vessels, and a central pink to white veil. In addition, in 2 patients a slight brownish homogenous pigmentation at the periphery of the lesion was observed. In one case the correct diagnosis was done by an experienced dermatologist using dermatoscopy, whereas in the remaining 6 cases the clinical diagnoses included squamous cell carcinoma, Bowen disease, pyogenic granuloma and basal cell carcinoma. In 2 of 6 patients amelanotic/hypomelanotic melanoma was associated with a previous history of melanoma. Conclusion: Amelanotic/hypomelanotic melanoma exhibits as a common dermatoscopic denominator atypical vessels, varying in size and shape, usually associated with a central pink to white veil.
Keyword Dermatology
Skin - Diseases
amelanotic/hypomelanotic melanoma
skin tumors
vessels
dermatoscopy

 
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Created: Thu, 19 Mar 2009, 18:12:49 EST by Ms Karen Naughton on behalf of School of Medicine