Developmental programming of a reduced nephron endowment: More than just a baby's birth-weight

Moritz, Karen M., Singh, Reetu R., Probyn, Megan E. and Denton, Kate M. (2009) Developmental programming of a reduced nephron endowment: More than just a baby's birth-weight. American Journal of Physiology - Renal Physiology, 296 1: F1-F9. doi:10.1152/ajprenal.00049.2008


Author Moritz, Karen M.
Singh, Reetu R.
Probyn, Megan E.
Denton, Kate M.
Title Developmental programming of a reduced nephron endowment: More than just a baby's birth-weight
Journal name American Journal of Physiology - Renal Physiology   Check publisher's open access policy
ISSN 1931-857X
1522-1466
Publication date 2009-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/ajprenal.00049.2008
Open Access Status
Volume 296
Issue 1
Start page F1
End page F9
Total pages 9
Editor T. R. Kleyman
B. B. Rauner
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Language eng
Subject 1314 Physiology
2748 Urology
Abstract Moritz KM, Singh RR, Probyn ME, Denton KM. Developmental programming of a reduced nephron endowment: more than just a baby's birth weight. Am J Physiol Renal Physiol 296: F1-F9, 2009. First published July 23, 2008; doi: 10.1152/ajprenal.00049.2008.-The risk of developing many adult- onset diseases, including hypertension, type 2 diabetes, and renal disease, is increased in low-birth-weight individuals. A potential underlying mechanism contributing to the onset of these diseases is the formation of a low nephron endowment during development. Evidence from the human, as well as many experimental animal models, has shown a strong association between low birth weight and a reduced nephron endowment. However, other animal models, particularly those in which the mother is exposed to elevated glucocorticoids for a short period, have shown a 20-40% reduction in nephron endowment without discernible changes in the birth weight of offspring. Such findings emphasize that a low birth weight is one, but certainly not the only, predictor of nephron endowment and suggests reduced nephron endowment and risk of developing adult-onset disease, even among normal-birth-weight individuals. Recognition of the dissociation between birth weight and nephron endowment is important for future studies aimed at elucidating the role of a reduced nephron endowment in the developmental programming of adult disease.
Formatted abstract
The risk of developing many adult onset diseases, including hypertension, type II diabetes and renal disease is increased in individuals born of a low birth weight. A potential underlying mechanism contributing to the onset of these diseases is the formation of a low nephron endowment during development. Evidence from the human, as well as many experimental animal models, has found a strong association between being born of a low weight and having a reduced nephron endowment. However, other animal models, particularly those in which the mother is exposed to elevated glucocorticoids for a short period, have shown a 20-40% reduction in nephron endowment without discernible changes in the birth weight of offspring. This highlights that a low birth weight is one but certainly not the only predictor of nephron endowment and suggests that even individuals born of a normal birth weight could potentially have a reduced nephron endowment and be at risk of developing adult onset disease. Recognition of the dissociation between birth-weight and nephron endowment is important for future studies aimed at elucidating the role of a reduced nephron endowment in the developmental programming of adult disease. Key words: development, hypertension, glucocorticoid exposure.

Keyword Glucocorticoid exposure
Kidney development
Hypertension
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published July 23, 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Biomedical Sciences Publications
 
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Created: Wed, 18 Mar 2009, 22:05:51 EST