Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease

Murrell, Wayne, Wetzig, Andrew, Donnellan, Michael, Féron, François, Burne, Tom, Meedeniya, Adrian, Kesby, James, Bianco, John, Perry, Chris, Silburn, Peter and Mackay-Sim, Alan (2008) Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease. Stem Cells, 26 8: 2183-2192. doi:10.1634/stemcells.2008-0074


Author Murrell, Wayne
Wetzig, Andrew
Donnellan, Michael
Féron, François
Burne, Tom
Meedeniya, Adrian
Kesby, James
Bianco, John
Perry, Chris
Silburn, Peter
Mackay-Sim, Alan
Title Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease
Journal name Stem Cells   Check publisher's open access policy
ISSN 1066-5099
1549-4918
Publication date 2008-08-01
Year available 2008
Sub-type Article (original research)
DOI 10.1634/stemcells.2008-0074
Open Access Status DOI
Volume 26
Issue 8
Start page 2183
End page 2192
Total pages 10
Editor Ann Murphy
Place of publication Malden, MA, U.S.A.
Publisher AlphaMed Press, Inc
Language eng
Subject C1
10 Technology
1103 Clinical Sciences
Abstract Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic targets. We show here that neural progenitors can be grown from the olfactory organ of humans, including those with Parkinson's disease. These neural progenitors proliferated and generated dopami- nergic cells in vitro. They also generated clopaminergic cells when transplanted into the brain and reduced the behavioral asymmetry induced by ablation of the dopaminergic neurons in the rat model of Parkinson's disease. Our results indicate that Parkinson's patients could provide their own source of neuronal progenitors for cell transplantation therapies and for direct investigation of the biology and treatments of Parkinson's disease. ©AlphaMed Press
Keyword Parkinson's disease
Olfactory stem cell
Autologous cell therapy
Dopaminergic
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 18 Mar 2009, 22:05:32 EST