Nuclear Factor One Transcription Factors in CNS Development

Mason, Sharon, Piper, Michael, Gronostajski, Richard M. and Richards, Linda J. (2009) Nuclear Factor One Transcription Factors in CNS Development. Molecular Neurobiology, 39 1: 10-23. doi:10.1007/s12035-008-8048-6

Author Mason, Sharon
Piper, Michael
Gronostajski, Richard M.
Richards, Linda J.
Title Nuclear Factor One Transcription Factors in CNS Development
Journal name Molecular Neurobiology   Check publisher's open access policy
ISSN 0893-7648
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s12035-008-8048-6
Open Access Status Not Open Access
Volume 39
Issue 1
Start page 10
End page 23
Total pages 14
Editor Jacques Mallet
Nicolas G. Bazan
Place of publication United States
Publisher Humana Press Inc.
Language eng
Subject C1
110903 Central Nervous System
110902 Cellular Nervous System
920111 Nervous System and Disorders
Abstract Transcription factors are key regulators of central nervous system (CNS) development and brain function. Research in this area has now uncovered a new key player–the nuclear factor one (NFI) gene family. It has been almost a decade since the phenotype of the null mouse mutant for the nuclear factor one A transcription factor was reported. Nfia null mice display a striking brain phenotype including agenesis of the corpus callosum and malformation of midline glial populations needed to guide axons of the corpus callosum across the midline of the developing brain. Besides NFIA, there are three other NFI family members in vertebrates: NFIB, NFIC, and NFIX. Since generation of the Nfia knockout (KO) mice, KO mice for all other family members have been generated, and defects in one or more organ systems have been identified for all four NFI family members (collectively referred to as NFI here). Like the Nfia KO mice, the Nfib and Nfix KO mice also display a brain phenotype, with the Nfib KO forebrain phenotype being remarkably similar to that of Nfia. Over the past few years, studies have highlighted NFI as a key payer in a variety of CNS processes including axonal outgrowth and guidance and glial and neuronal cell differentiation. Here, we discuss the importance and role of NFI in these processes in the context of several CNS systems including the neocortex, hippocampus, cerebellum, and spinal cord at both cellular and molecular levels.
Keyword Pax6
Spinal cord
Cerebral cortex
Cellular differentiation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 50 times in Scopus Article | Citations
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Created: Tue, 17 Mar 2009, 23:55:43 EST by Debra McMurtrie on behalf of Queensland Brain Institute