fMRI adaptation reveals mirror neurons in human inferior parietal cortex

Chong, Trevor T-J., Cunnington, Ross, Williams, Mark A., Kanwisher, Nancy and Mattingley, Jason B. (2008) fMRI adaptation reveals mirror neurons in human inferior parietal cortex. Current Biology, 18 20: 1576-1580. doi:10.1016/j.cub.2008.08.068

Author Chong, Trevor T-J.
Cunnington, Ross
Williams, Mark A.
Kanwisher, Nancy
Mattingley, Jason B.
Title fMRI adaptation reveals mirror neurons in human inferior parietal cortex
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
Publication date 2008-10-25
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.cub.2008.08.068
Open Access Status DOI
Volume 18
Issue 20
Start page 1576
End page 1580
Total pages 5
Editor North, Gregory
Place of publication United States
Publisher Cell Press
Language eng
Subject C1
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
970117 Expanding Knowledge in Psychology and Cognitive Sciences
Abstract Mirror neurons, as originally described in the macaque, have two defining properties [1, 2]: They respond specifically to a particular action (e.g., bringing an object to the mouth), and they produce their action-specific responses independent of whether the monkey executes the action or passively observes a conspecific performing the same action. In humans, action observation and action execution engage a network of frontal, parietal, and temporal areas. However, it is unclear whether these responses reflect the activity of a single population that represents both observed and executed actions in a common neural code or the activity of distinct but overlapping populations of exclusively perceptual and motor neurons [3]. Here, we used fMRI adaptation to show that the right inferior parietal lobe (IPL) responds independently to specific actions regardless of whether they are observed or executed. Specifically, responses in the right IPL were attenuated when participants observed a recently executed action relative to one that had not previously been performed. This adaptation across action and perception demonstrates that the right IPL responds selectively to the motoric and perceptual representations of actions and is the first evidence for a neural response in humans that shows both defining properties of mirror neurons.
Keyword Biochemistry & Molecular Biology
Cell Biology
Biochemistry & Molecular Biology
Cell Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID EY13455
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 188 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 11 Mar 2009, 23:55:06 EST by Debra McMurtrie on behalf of Queensland Brain Institute