Change in cortical bone density and its distribution differs between boys and girls during puberty

Kontulainen, Saija A., Macdonald, Heather M. and McKay, Heather A. (2006) Change in cortical bone density and its distribution differs between boys and girls during puberty. Journal of Clinical Endocrinology and Metabolism, 91 7: 2555-2561. doi:10.1210/jc.2006-0136


Author Kontulainen, Saija A.
Macdonald, Heather M.
McKay, Heather A.
Title Change in cortical bone density and its distribution differs between boys and girls during puberty
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
1945-7197
Publication date 2006-07-01
Sub-type Article (original research)
DOI 10.1210/jc.2006-0136
Open Access Status
Volume 91
Issue 7
Start page 2555
End page 2561
Total pages 7
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Concept: Postmenarchal girls and premenopausal women have 3–4% higher cortical bone density (CoD, milligrams per cubic centimeter), compared with postpubertal boys and men, respectively. Females’ denser cortical bone is thought to serve as a calcium reservoir for reproductive needs. However, prospective data are lacking that describe CoD development and bone mineral density distribution during puberty in both sexes.

Objective: Thus, our objectives were to assess maturity and sex differences in the 20-month change of CoD and radial distribution of bone mineral density (RDBMD, milligrams per cubic centimeter) in early-, peri-, and postpubertal girls and boys. Maturity groups were based on change in menarcheal status (girls, n = 68) and pubic hair stage (Tanner) (boys, n = 59). Peripheral quantitative computed tomography was used to measure CoD and RDBMD at the tibial middiaphysis.

Results: The increase in average CoD was 1.9% [22.8 mg/cm3; 95% confidence interval (CI), 10–36], 2.8% (33.8 mg/cm3; 95% CI, 21–47), and 1.5% (55.0 mg/cm3; 95% CI, 17–93) greater in early, peri-, and postpubertal girls, compared with boys, respectively. Analysis of RDBMD revealed that the change in density distribution varied across pubertal groups in girls. Across puberty, all girls showed an increase in the high density midcortical region, whereas only peripubertal girls showed an increase in the lower density subcortical region. A sex-difference in RDBMD change was noted within early and peripubertal groups.

Conclusions: Our findings of sexual dimorphism in CoD development give support to the hypothesis that female bone deposits calcium for reproductive needs by consolidation of cortical bone during puberty.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Issue section: "Endocrine Care"

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 10 Mar 2009, 01:34:05 EST by Ms Lynette Adams on behalf of School of Human Movement and Nutrition Sciences