The role of cyclic nucleotides in axon guidance

Piper, Michael, van Horck, Francis and Holt, Christine (2007). The role of cyclic nucleotides in axon guidance. In Dominique Bagnard (Ed.), Axon growth and guidance (pp. 134-143) New York, NY, United States: Springer. doi:10.1007/978-0-387-76715-4_10

Author Piper, Michael
van Horck, Francis
Holt, Christine
Title of chapter The role of cyclic nucleotides in axon guidance
Title of book Axon growth and guidance
Place of Publication New York, NY, United States
Publisher Springer
Publication Year 2007
Sub-type Research book chapter (original research)
DOI 10.1007/978-0-387-76715-4_10
Open Access Status DOI
Series Advances in Experimental Medicine and Biology
ISBN 9780387767147
ISSN 0065-2598
Editor Dominique Bagnard
Volume number 621
Chapter number 10
Start page 134
End page 143
Total pages 10
Total chapters 1
Language eng
Subjects 1109 Neurosciences
Abstract/Summary During the formation of the nervous system, axonal growth cones navigate through the complex environment of the developing embryo to innervate their targets. Growth cones achieve this formidable feat by responding to attractive or repulsive guidance cues expressed at specific points along the trajectory of their growth, which impart the directional information required for accurate pathfinding. While much is known about guidance molecules and their receptors, many questions remain unanswered. Which signal transduction pathways are activated within the growth cone after encountering a guidance cue? How is this related to rearrangement of the growth cone cytoskeleton? Do different cues use different signal transduction pathways? This chapter will review some of the work that has addressed these fundamental question, with a specific focus on the role of the cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), in axon guidance.
Keyword Cyclic nucleotides
Axon guidance
Q-Index Code B1
Institutional Status Non-UQ

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