Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster

Passador-Gurgel, Gisele, Hsieh, Wen-Ping, Hunt, Priscilla, Deighton, Nigel and Gibson, Greg (2007) Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Nature Genetics, 39 2: 264-268. doi:10.1038/ng1944


Author Passador-Gurgel, Gisele
Hsieh, Wen-Ping
Hunt, Priscilla
Deighton, Nigel
Gibson, Greg
Title Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster
Formatted title
Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1038/ng1944
Open Access Status DOI
Volume 39
Issue 2
Start page 264
End page 268
Total pages 5
Place of publication New York
Publisher Nature America Inc
Language eng
Subject 1103 Clinical Sciences
Abstract Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance. The strongest association was seen for abundance of ornithine aminotransferase transcripts, implicating detoxification and neurotransmitter biosynthesis as mediators of the quantitative response to the drug. Subsequently, genetic analysis and metabolite profiling confirmed a complex role for ornithine and GABA levels in modification of survival time upon chronic nicotine exposure. Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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