The embryonic human choriocapillaris develops by hemo-vasculogenesis

Hasegawa, Takuya, McLeod, D. Scott, Bhutto, Imran A., Prow, Tarl, Merges, Carol A., Grebe, Rhonda and Lutty, Gerard A. (2007) The embryonic human choriocapillaris develops by hemo-vasculogenesis. Developmental dynamics, 236 8: 2089-2100. doi:10.1002/dvdy.21231


Author Hasegawa, Takuya
McLeod, D. Scott
Bhutto, Imran A.
Prow, Tarl
Merges, Carol A.
Grebe, Rhonda
Lutty, Gerard A.
Title The embryonic human choriocapillaris develops by hemo-vasculogenesis
Journal name Developmental dynamics   Check publisher's open access policy
ISSN 1097-0177
1058-8388
Publication date 2007-08-01
Year available 2007
Sub-type Article (original research)
DOI 10.1002/dvdy.21231
Open Access Status DOI
Volume 236
Issue 8
Start page 2089
End page 2100
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 060103 Cell Development, Proliferation and Death
Formatted abstract
The purpose of this study was to characterize normal human choroidal vascular development from 6-23 weeks gestation (WG). Markers of endothelial cells (EC) (CD34, CD31, vWf), angioblasts and EC (CD39), leukocytes (CD45), erythroblasts (epsilon chain of hemoglobin, Hb-e), proliferating cells (Ki67), and VEGFR-2 were employed. At 6-7 WG, many erythroblasts were observed within islands of precursor cells in the choriocapillaris layer and others were independent from the islands. Many erythroblasts (Hb-ε+) were also positive for EC markers and/or VEGFR-2. By 8-12 WG, most of the Hb-ε cells had disappeared and vascular lumens became apparent. At 14-23 WG, some EC were proliferating on the scleral side of choriocapillaris in association with forming deeper vessels. In conclusion, embryonic choriocapillaris appears to form initially by hemo-vasculogenesis (blood vessels and blood cells form simultaneously from common precursors) while angiogenesis appears to be the mode of intermediate and large choroidal vessel development in the fetus
Keyword Choroids
Hemo-vasculogenesis
Hemangioblasts
Angiogenesis
Vascular precursors
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID P30 EY001765
Institutional Status Non-UQ

 
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Created: Fri, 13 Feb 2009, 19:50:10 EST by Ms Lynette Adams on behalf of Aust Institute for Bioengineering & Nanotechnology