Molecular dynamics study of the metallochaperone Hah1 in its apo and Cu(I)-loaded states: Role of the conserved residue M10

Poger, David, Fuchs, Jean-Francois, Nedev, Hristo, Ferrand, Michel and Crouzy, Serge (2005) Molecular dynamics study of the metallochaperone Hah1 in its apo and Cu(I)-loaded states: Role of the conserved residue M10. Febs Letters, 579 24: 5287-5292. doi:10.1016/j.febslet.2005.08.052


Author Poger, David
Fuchs, Jean-Francois
Nedev, Hristo
Ferrand, Michel
Crouzy, Serge
Title Molecular dynamics study of the metallochaperone Hah1 in its apo and Cu(I)-loaded states: Role of the conserved residue M10
Journal name Febs Letters   Check publisher's open access policy
ISSN 0014-5793
Publication date 2005-10-10
Sub-type Article (original research)
DOI 10.1016/j.febslet.2005.08.052
Volume 579
Issue 24
Start page 5287
End page 5292
Total pages 6
Place of publication Amsterdam
Publisher Elsevier
Language eng
Subject 029901 Biological Physics
060112 Structural Biology (incl. Macromolecular Modelling)
Abstract Molecular dynamics simulations were performed on both apo and copper forms of the human copper chaperone, Hah1. Wild-type Hah1 and a methionine (M10) to serine mutant were investigated. We have evidenced the central role of residue M10 in stabilizing the hydrophobic core of Hah1 as well as the internal structure of the metal-binding site. When copper(I) is bound, the mobility of Hah1 is reduced whereas mutation of M10 implies a drastic increase of the mobility of apoHah1, stressing the importance of this highly conserved hydrophobic residue for copper sequestration by the apoprotein.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 12 Feb 2009, 22:14:03 EST by Maryanne Watson on behalf of Library Corporate Services