Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua

Zhang, Hua, Wang, Xiao-Ning, Lin, Li-Ping, Ding, Jian and Yue, Jian-Min (2007) Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua. Journal of Natural Products, 70 1: 54-59. doi:10.1021/np060344o


Author Zhang, Hua
Wang, Xiao-Ning
Lin, Li-Ping
Ding, Jian
Yue, Jian-Min
Title Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua
Formatted title
Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2007-01-05
Sub-type Article (original research)
DOI 10.1021/np060344o
Open Access Status
Volume 70
Issue 1
Start page 54
End page 59
Total pages 6
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 030502 Natural Products Chemistry
Formatted abstract
Six new indole alkaloids, 14,15-didehydro-10,11-dimethoxy-16-epivincamine (1), 14,15-didehydro-10-hydroxy-11-methoxy-16-epivincamine (2), 14,15-didehydro-10,11-dimethoxyvincamine (3), 14,15-didehydro-10-hydroxy-11-methoxyvincamine (4), 19,20-didehydro-6α-hydroxyervatamine (5), and dehydroxyervataminol (6), along with 36 known indole alkaloids, were isolated from three species, E. officinalis, E. divaricata, and E. divaricata Gouyahua, of the Ervatamia genus. The structures of these alkaloids were characterized on the basis of spectroscopic methods and chemical correlation. The in vitro cytotoxic activities of all the alkaloids except 7, 18, 27, 38, 40, and 44 against the tumor cell lines P-388 murine leukemia and A-549 human lung carcinoma were evaluated. Only the dimeric indole alkaloids showed cytotoxic activities.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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