An Attractive Surface: Gram-Negative Bacterial Biofilms

Schembri, Mark A., Givskov, Michael and Klemm, Ker (2002) An Attractive Surface: Gram-Negative Bacterial Biofilms. Signal Transduction Knowledge Environment, 132 RE6. doi:10.1126/stke.2002.132.re6

Author Schembri, Mark A.
Givskov, Michael
Klemm, Ker
Title An Attractive Surface: Gram-Negative Bacterial Biofilms
Journal name Signal Transduction Knowledge Environment   Check publisher's open access policy
ISSN 1525-8882
Publication date 2002-05-14
DOI 10.1126/stke.2002.132.re6
Volume 132
Start page RE6
Place of publication Washington, DC
Publisher American Association for the Advancement of Science
Language eng
Subject 0605 Microbiology
Abstract nature, most bacteria live in close association with surfaces as complex communities referred to as biofilms. Community members within these compact microbial consortia show extraordinary resistance to conventional antibiotics, biocides, and hydrodynamic shear forces when compared to their planktonic counterparts. The buildup of these surface-associated bacterial communities is a highly organized and complex process that requires many signal transduction mechanisms to orchestrate the different stages of development. In this review, we describe several types of signal transduction that Gram-negative bacteria employ during the adhesion and expansion stages of biofilm formation, as well as discuss quorum-sensing in relation to the production of virulence factors.

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