Endothelial cell migration directs testis cord formation

Combes, AN, Wilhelm, D, Davidson, T, Dejana, E, Harley, V, Sinclair, A and Koopman, P (2009) Endothelial cell migration directs testis cord formation. Developmental Biology, 326 1: 112-120. doi:10.1016/j.ydbio.2008.10.040

Author Combes, AN
Wilhelm, D
Davidson, T
Dejana, E
Harley, V
Sinclair, A
Koopman, P
Title Endothelial cell migration directs testis cord formation
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
Publication date 2009-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2008.10.040
Open Access Status
Volume 326
Issue 1
Start page 112
End page 120
Total pages 9
Place of publication San Diego, Calif., U. S. A.
Publisher Academic Press
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
270205 Genetic Development (incl. Sex Determination)
Formatted abstract
While the molecular cues initiating testis determination have been identified in mammals, the cellular interactions involved in generating a functional testis with cord and interstitial compartments remain poorly understood. Previous studies have shown that testis cord formation relies on cell migration from the adjacent mesonephros, and have implicated immigrant peritubular myoid cells in this process. Here, we used recombinant organ culture experiments to show that immigrant cells are endothelial, not peritubular myoid or other interstitial cells. Inhibition of endothelial cell migration and vascular organisation using a blocking antibody to VE-cadherin, also disrupted the development of testis cords. Our data reveal that migration of endothelial cells is required for testis cord formation, consistent with increasing evidence of a broader role for endothelial cells in establishing tissue architecture during organogenesis.
Crown Copyright © 2008 Published by Elsevier Inc. All rights reserved.
Keyword Organogenesis
Cell migration
Testis development
Endothelial cells
Organ culture
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 7 November 2008

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Created: Tue, 03 Feb 2009, 21:10:18 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience