Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera

McGrath, J. J., Eyles, Darryl Walter, Mowry, Bryan, Yolken, R. and Buka, S. (2003) Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophrenia Research, 63 1 - 2: 73-78. doi:10.1016/S0920-9964(02)00435-8


Author McGrath, J. J.
Eyles, Darryl Walter
Mowry, Bryan
Yolken, R.
Buka, S.
Title Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 2003-09-01
Sub-type Article (original research)
DOI 10.1016/S0920-9964(02)00435-8
Volume 63
Issue 1 - 2
Start page 73
End page 78
Total pages 6
Editor Nasrallah, H. A.
DeLisi, L. E.
Place of publication Amsterdam
Publisher Elsevier
Language eng
Subject 1109 Neurosciences
111714 Mental Health
Abstract Objective: Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. Method: Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected controls. For each case, we selected two controls matched on race, gender and date of birth of the offspring. Results: There was no significant difference in third trimester maternal vitamin D in the entire sample (cases=26, CONTROLS=51). Within the subgroup of black individuals (n=21), there was a trend level difference in the predicted direction. Conclusions: Maternal vitamin D does not operate as a continuous graded risk factor for schizophrenia, however, the results in the black subgroup raise the possibility that below a certain critical threshold, low levels of maternal vitamin D may be associated with an increased risk of schizophrenia.
Keyword Vitamin D
Schizophrenia
Banked sera
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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