Ponapensin, a cyclopenta(bc)benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis

Salim, Angela A., Pawlus, Alison D., Chai, Hee-Byung, Farnsworth, Norman R., Kinghorn, A. Douglas and Carcache-Blanco, Esperanza J. (2007) Ponapensin, a cyclopenta(bc)benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis. Bioorganic & Medicinal Chemistry Letters, 17 1: 109-112. doi:10.1016/j.bmcl.2006.09.084


Author Salim, Angela A.
Pawlus, Alison D.
Chai, Hee-Byung
Farnsworth, Norman R.
Kinghorn, A. Douglas
Carcache-Blanco, Esperanza J.
Title Ponapensin, a cyclopenta(bc)benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis
Journal name Bioorganic & Medicinal Chemistry Letters   Check publisher's open access policy
ISSN 1464-3405
0960-894X
Publication date 2007-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.bmcl.2006.09.084
Open Access Status DOI
Volume 17
Issue 1
Start page 109
End page 112
Total pages 4
Place of publication Oxford
Publisher Pergamon Press/ELsevier
Language eng
Subject 030401 Biologically Active Molecules
030502 Natural Products Chemistry
Abstract Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl3 soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation. Ponapensin (1) exhibited significant NF-κB inhibitory activity in an Elisa assay, and was found to be more potent than the positive control rocaglamide. All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances.
Keyword Chemistry, Medicinal
Chemistry, Organic
Pharmacology & Pharmacy
Chemistry
CHEMISTRY, MEDICINAL
CHEMISTRY, ORGANIC
Q-Index Code C1
Grant ID U19 CA052956
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 30 Jan 2009, 00:51:19 EST by Paul Rollo on behalf of Institute for Molecular Bioscience