The Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sbp gene

Rowland, S. L., Errington, J. and Wake, R. G. (1995) The Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sbp gene. Gene, 164 1: 113-116. doi:10.1016/0378-1119(95)00467-K


Author Rowland, S. L.
Errington, J.
Wake, R. G.
Title The Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sbp gene
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
Publication date 1995-10-16
Year available 1995
Sub-type Article (original research)
DOI 10.1016/0378-1119(95)00467-K
Volume 164
Issue 1
Start page 113
End page 116
Total pages 4
Place of publication Amsterdam
Publisher Elsevier/North Holland
Language eng
Subject 060199 Biochemistry and Cell Biology not elsewhere classified
060501 Bacteriology
Abstract Sequence similarity analysis has revealed that orf2, in the cell division 135-137 degrees region of the Bacillus subtilis (Bs) chromosome, is the probable homolog of Escherichia coli murB (encoding a reductase involved in peptidoglycan synthesis). The amino-acid sequences of the two protein products show 24% identity (47% overall similarity), with several regions of higher similarity which may represent functional domains of the proteins. Attempts to insertionally inactivate orf2 were unsuccessful, strongly suggesting that it is an essential Bs gene. A small gene found in the same region as orf2, sbp (encoding the 'small basic protein'), was shown to be non-essential in Bs.
Keyword Cell division
conservation
essential gene
MurB homolog
Sbp homolog
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 21 Jan 2009, 00:10:07 EST by Ms Karen Naughton on behalf of Institute for Molecular Bioscience