The KNOTTIN website and database: a new information system dedicated to the knottin scaffold

Gelly, Jean-Christophe, Gracy, Jérôme, Kaas, Quentin, Le-Nguyen, Dung, Heitz, Annie and Chiche, Laurent (2004) The KNOTTIN website and database: a new information system dedicated to the knottin scaffold. Nucleic acids research, 32(Database edition) D156-D159. doi:10.1093/nar/gkh015


Author Gelly, Jean-Christophe
Gracy, Jérôme
Kaas, Quentin
Le-Nguyen, Dung
Heitz, Annie
Chiche, Laurent
Title The KNOTTIN website and database: a new information system dedicated to the knottin scaffold
Journal name Nucleic acids research   Check publisher's open access policy
ISSN 0305-1048
1362-4962
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1093/nar/gkh015
Open Access Status DOI
Volume 32(Database edition)
Start page D156
End page D159
Total pages 4
Place of publication Oxford
Publisher Oxford University Press
Language eng
Subject 060102 Bioinformatics
060112 Structural Biology (incl. Macromolecular Modelling)
Abstract The KNOTTIN website and database organize information about knottins or inhibitor cystine knots, small disulfide-rich proteins with a knotted topology. Thanks to their small size and high stability, knottins provide appealing scaffolds for protein engineering and drug design. Static pages present the main historical and recent results about knottin discoveries, sequences, structures, folding, functions, applications and bibliography. Database searches provide dynamically generated tabular reports or sequence alignments for knottin three-dimensional structures or sequences. BLAST/HMM searches are also available. A simple nomenclature, based on loop lengths between cysteines, is proposed and is complemented by a uniform numbering scheme. This standardization is applied to all knottin structures in the database, facilitating comparisons. Renumbered and structurally fitted knottin PDB files are available for download. The standardized numbering is used for automatic drawing of two-dimensional Colliers de Perles. The KNOTTIN website and database are available at http://knottin.cbs.cnrs.fr and http://knottin.com.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
BIOCHEMISTRY & MOLECULAR BIOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 20 Jan 2009, 23:11:57 EST by Ms Karen Naughton on behalf of Institute for Molecular Bioscience