Gene expression profiling reveals multiple novel intrinsic and extrinsic factors associated with axonal regeneration failure

Küry, Patrick, Abankwa, Daniel, Kruse, Fabian, Greiner-Petter, Regine and Müller, Hans Werner (2004) Gene expression profiling reveals multiple novel intrinsic and extrinsic factors associated with axonal regeneration failure. European journal of neuroscience, 19 1: 32-42. doi:10.1111/j.1460-9568.2004.03112.x


Author Küry, Patrick
Abankwa, Daniel
Kruse, Fabian
Greiner-Petter, Regine
Müller, Hans Werner
Title Gene expression profiling reveals multiple novel intrinsic and extrinsic factors associated with axonal regeneration failure
Journal name European journal of neuroscience   Check publisher's open access policy
ISSN 0953-816X
1460-9568
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2004.03112.x
Open Access Status DOI
Volume 19
Issue 1
Start page 32
End page 42
Total pages 11
Place of publication Oxford
Publisher Blackwell
Language eng
Subject 060408 Genomics
060103 Cell Development, Proliferation and Death
060105 Cell Neurochemistry
Abstract In contrast to the regeneration-competent peripheral nervous system (PNS), lesions of nerve tracts within the central nervous system (CNS) lead to chronically impaired neuronal connections. We have analysed changes in gene expression patterns occurring as a consequence of postcommissural fornix transection at a time when spontaneous axonal growth has ceased at the lesion site. This was done in order to describe both extrinsic and intrinsic determinants of regeneration failure. Using a genomic approach we have identified a number of so far undetected factors such as bamacan and semaphorin 6B, which relate to chronic axonal growth arrest and therefore are promising candidates for lesion-induced axonal growth inhibitors. In addition, we observed that within the subiculum, where the fornix axons originate, neuronal Oct-6 was induced and NG2 was down-regulated, indicating that axotomized neurons as well as glial cells react at the level of gene expression to remote axotomy
Keyword axotomy
central nervous system
DNA array
lesion site
regeneration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
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