Regulation of pancreatic β-cell function by adipocytes

Zhao, Y. F. and Chen, C. (2007) Regulation of pancreatic β-cell function by adipocytes. Shengli Xuebao (Acta physiologica Sinica), 59 3: 247-252.

Author Zhao, Y. F.
Chen, C.
Title Regulation of pancreatic β-cell function by adipocytes
Journal name Shengli Xuebao (Acta physiologica Sinica)   Check publisher's open access policy
ISSN 0371-0874
Publication date 2007-06-25
Sub-type Article (original research)
Volume 59
Issue 3
Start page 247
End page 252
Total pages 6
Place of publication China
Publisher Science Press
Language eng
Subject 110306 Endocrinology
110201 Cardiology (incl. Cardiovascular Diseases)
111201 Cancer Cell Biology
Abstract Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
Keyword Adipokines
Bioactive factors
Pancreatic beta-cell
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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