Pharmacogenetics of the arylamine N-acetyltransferases

Butcher, N. J., Boukouvala, S., Sim, E. and Minchin, R. F. (2002) Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics Journal, 2 1: 30-42.


Author Butcher, N. J.
Boukouvala, S.
Sim, E.
Minchin, R. F.
Title Pharmacogenetics of the arylamine N-acetyltransferases
Formatted title
Pharmacogenetics of the arylamine N-acetyltransferases
Journal name Pharmacogenomics Journal   Check publisher's open access policy
ISSN 1470-269X
Publication date 2002
Volume 2
Issue 1
Start page 30
End page 42
Total pages 13
Place of publication Avenet, NJ
Publisher Nature Pub. Group
Language eng
Subject 111505 Pharmacogenomics
Abstract The arylamine N-acetyltransferases (NATs) are involved in the metabolism of a variety of different compounds that we are exposed to on a daily basis. Many drugs and chemicals found in the environment, such as those in cigarette smoke, car exhaust fumes and in foodstuffs, can be either detoxified by NATs and eliminated from the body or bioactivated to metabolites that have the potential to cause toxicity and/or cancer. NATs have been implicated in some adverse drug reactions and as risk factors for several different types of cancers. As a result, the levels of NATs in the body have important consequences with regard to an individual's susceptibility to certain drug-induced toxicities and cancers. This review focuses on recent advances in the molecular genetics of the human NATs.
Keyword N-acetyltransferase
NAT
acetylation
arylamine
polymorphism

 
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Created: Wed, 07 Jan 2009, 17:35:16 EST by Sophie Jordan on behalf of School of Biomedical Sciences