Genetics of alcohol and tobacco use in humans

Tyndale, Rachel F. (2003) Genetics of alcohol and tobacco use in humans. Annals of Medicine, 35 2: 94-121. doi:10.1080/07853890310010014

Author Tyndale, Rachel F.
Title Genetics of alcohol and tobacco use in humans
Journal name Annals of Medicine   Check publisher's open access policy
ISSN 0785-3890
Publication date 2003-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/07853890310010014
Open Access Status Not Open Access
Volume 35
Issue 2
Start page 94
End page 121
Total pages 28
Place of publication Helsinki, Finland
Publisher Taylor and Franics
Language eng
Subject 1103 Clinical Sciences
Abstract The field of genetics holds great promise for furthering our understanding of the etiology of drug dependence and for identifying novel targets for treatment. Genetic studies utilizing twins and families have demonstrated a considerable role for genetics in nicotine and/or alcohol dependence. Risk for alcoholism or nicotine dependence is likely to be the result of a large number of genes, each contributing a small fraction of the overall risk. While this review will focus on studies in humans, many of the candidate genes for human nicotine and alcohol dependence listed here were originally postulated to be important, based on data from animal studies. The review will briefly summarize the results from twin and adoption studies that provide estimations of heritability, the results from chromosomal linkage studies that identify regions of chromosomes that may contain relevant genes, and the results of candidate gene studies. For each topic the data will be presented for nicotine dependence, alcohol dependence, and for nicotine and alcohol dependence together. In addition, each section will review briefly some of the confounding issues in the specific type of approach utilized.
Keyword alcoholism
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 154 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 185 times in Scopus Article | Citations
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Created: Fri, 29 Aug 2008, 03:25:32 EST