Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy

Walton, Robert, Johnstone, Elaine, Munafo, Marcus, Neville, Matt and Griffiths, Siân (2001) Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy. Trends in Molecular Medicine, 7 2: 70-76. doi:10.1016/S1471-4914(01)01915-3


Author Walton, Robert
Johnstone, Elaine
Munafo, Marcus
Neville, Matt
Griffiths, Siân
Title Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy
Journal name Trends in Molecular Medicine   Check publisher's open access policy
ISSN 1471-4914
Publication date 2001-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1471-4914(01)01915-3
Open Access Status DOI
Volume 7
Issue 2
Start page 70
End page 76
Total pages 6
Place of publication Amsterdam
Publisher Elseveier
Language eng
Subject 1101 Medical Biochemistry and Metabolomics
Abstract The molecular processes that underlie addiction are beginning to unfold. Genetically determined variations in dopaminergic neurotransmission predispose to nicotine dependence. In addition, tobacco use is likely to be governed by the rate at which smokers metabolize nicotine. Functional polymorphisms in CYTOCHROME P450 monooxygenases that metabolize nicotine have now been defined and it should soon be possible to identify fast nicotine metabolizers by DNA analysis. Here, we review the key neurotransmitter receptors and metabolic enzymes implicated in tobacco dependence. We explore the potential benefits of classifying smokers according to the molecular aetiology of their habit. One major benefit will be in planning effective strategies for smoking cessation. Methods of typing for alleles related to smoking behavior that might be suitable for use in clinical practice in the future will also be discussed
Keyword Addiction;
Cytochrome P450
neurotransmitter receptors
Nicotine
Tobacco
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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Created: Fri, 29 Aug 2008, 03:10:32 EST