Measuring exposure to S. japonicum in China. II. Activity diaries, pathways to infection and immunological correlates

Ross, Allen G. P., Sleigh, Adrian C., Li, Yuesheng, Williams, Gail M., Waine, Gary J., Forsyth, Simon J., Yi, Li, Hartel, Gunter F. and McManus, Donald P. (1998) Measuring exposure to S. japonicum in China. II. Activity diaries, pathways to infection and immunological correlates. Acta Tropica, 71 3: 229-236. doi:10.1016/S0001-706X(98)00062-X


Author Ross, Allen G. P.
Sleigh, Adrian C.
Li, Yuesheng
Williams, Gail M.
Waine, Gary J.
Forsyth, Simon J.
Yi, Li
Hartel, Gunter F.
McManus, Donald P.
Title Measuring exposure to S. japonicum in China. II. Activity diaries, pathways to infection and immunological correlates
Journal name Acta Tropica   Check publisher's open access policy
ISSN 1873-6254
0001-706X
Publication date 1998-11-30
Sub-type Article (original research)
DOI 10.1016/S0001-706X(98)00062-X
Volume 71
Issue 3
Start page 229
End page 236
Total pages 8
Place of publication Oxford
Publisher Elsevier B.V.
Language eng
Abstract In this study we examine the pathways to schistosomiasis exposure and infection among residents residing on two islands (large, Qingshan; small, Niangashan) in the Dongting Lake region (Hunan province) of China. An exposure model, based on activity diaries, was used to quantify an individual's square-metre-minute (sq.m.min) daily water contact. Subjects living on the small island had a significantly higher (P=0.0002) degree of exposure (mean±S.D., 13.2±11.0 sq.m.min) than individuals dwelling on the large island (mean±S.D., 5.5±7.1 sq.m.min). Participants identified as stool egg positive (mean±S.D., 8.3±10.4 sq.m.min) had higher exposures than for those never treated (mean±S.D., 2.2±3.4 sq.m.min) for schistosomiasis, and these high exposures rose steadily to peak at 35-49 years of age and decline after age 50. This exposure pattern differs markedly from those reported for African or South American schistosomiasis. The majority of human water contact occurs on the lake. Egg-positive subjects reported significantly higher (P<0.05) episodes of water contact on the lake versus their egg-negative counterparts, who reported significantly higher (P<0.01) exposure at the aquaculture ponds. The results of path analysis revealed that sex, age, island of residence and whether a fisherman or not were the most highly significant independent predictors of lake exposure. This accounted for approximately 40% (R2=0.39) of the total lake exposure. Exposure to lake water was a strong predictor (P=0.0006) of past infection and a modest predictor (P=0.05) of current infection. Copyright (C) 1998 Elsevier Science B.V.
Keyword Activity diaries
China
Human exposure
Path analysis
Schistosomiasis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
School of Medicine Publications
 
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