Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients

Stedman, Terry, Whiteford, Harvey, Eyles, Darryl, Welham, Joy and Pond, Susan (1991) Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients. Journal of Clinical Psychopharmacology, 11 1: 43-47.

Author Stedman, Terry
Whiteford, Harvey
Eyles, Darryl
Welham, Joy
Pond, Susan
Title Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients
Journal name Journal of Clinical Psychopharmacology   Check publisher's open access policy
ISSN 0271-0749
Publication date 1991-02-01
Sub-type Article (original research)
Volume 11
Issue 1
Start page 43
End page 47
Total pages 5
Place of publication Baltimore, Md.
Publisher Williams & Wilkins
Language eng
Subject 06 Biological Sciences
Abstract In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scale scores were observed. A significant reduction in Abnormal Involuntary Movement Scale scores was observed in those patients with tardive dyskinesia. After the addition of nifedipine, four of the 10 patients showed large increases in plasma neuroleptic activity (radioreceptor assay) that decreased to baseline levels within two weeks. The possibility that this represents competitive inhibition and subsequent induction of the liver metabolism of the antipsychotic drugs is discussed. Adverse effects encountered are also discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
School of Biological Sciences Publications
 
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Created: Fri, 29 Aug 2008, 02:18:34 EST