Autism is not associated with the fragile X syndrome

Einfeld, Stewart, Molony, Helen and Hall, Wayne (1989) Autism is not associated with the fragile X syndrome. American Journal of Medical Genetics, 34 2: 187-193. doi:10.1002/ajmg.1320340211


Author Einfeld, Stewart
Molony, Helen
Hall, Wayne
Title Autism is not associated with the fragile X syndrome
Journal name American Journal of Medical Genetics   Check publisher's open access policy
ISSN 1552-4868
Publication date 1989-10-01
Year available 1989
Sub-type Article (original research)
DOI 10.1002/ajmg.1320340211
Open Access Status DOI
Volume 34
Issue 2
Start page 187
End page 193
Total pages 7
Place of publication New York
Publisher Wiley-Liss
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Abstract We provided a controlled test of the hypothesis that individuals with the Martin-Bell or Fragile X [fra(x)] syndrome are more autistic than mentally retarded control individuals. A sample of fra(x) individuals was obtained from the register of a clinical genetics unit and compared with mentally retarded control individuals selected from an assessment centre who were individually matched for age, sex, and IQ. A comparison of 45 pairs of fra(x) cases and control individuals on the DSM-III (R) criteria for autism and two standardized instruments for the assessment of autism (ABC and ADC) failed to find a higher prevalence of autism among fra(x) individuals. There was no statistically significant difference between fra(x) individuals and control individuals, and the mean differences on both the ABC and ADC scales were in the direction contrary to the hypothesis. An analysis of the study's statistical power suggested that it is unlikely the investigation failed to detect a large to medium difference between fra(x) individuals and control individuals in autistic behaviour. Subsidiary analyses of case-control differences showed that two autistic-like behaviours occurred at a higher rate among fra(x) individuals than other mentally retarded children, namely, gaze avoidance and hand flapping. These abnormalities may have misled clinicians into thinking that autism and fra(x) are associated.
Keyword DSM III (R) criteria
Martin-Bell syndrome
fra(x) individuals
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Fri, 29 Aug 2008, 02:10:29 EST