Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice

Harms, Lauren R., Eyles, Darryl W., McGrath, John J., Mackay-Sim, Alan and Burne, Thomas H. J. (2008) Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice. Behavioural Brain Research, 187 2: 343-350. doi:10.1016/j.bbr.2007.09.032


Author Harms, Lauren R.
Eyles, Darryl W.
McGrath, John J.
Mackay-Sim, Alan
Burne, Thomas H. J.
Title Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
1872-7549
Publication date 2008-03-05
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.bbr.2007.09.032
Open Access Status Not Open Access
Volume 187
Issue 2
Start page 343
End page 350
Total pages 9
Editor Joe Huston
T. E. Robinson
Place of publication Amsterdam
Publisher Elsevier/North-Holland
Language eng
Subject 11 Medical and Health Sciences
C1
110902 Cellular Nervous System
Abstract Developmental vitamin D (DVD) deficiency has been proposed as an environmental risk factor for a number of brain disorders. The absence of this vitamin during foetal development in the rat is known to alter behaviour in the adult, and many of these alterations are informative with respect to the clinical features of schizophrenia. Here we investigated whether DVD deficiency had a similar effect on 129/SvJ and C57BL/6J mice. Female mice were fed a diet deficient in vitamin D for 6 weeks prior to conception until birth, after which dams and their offspring were fed a normal diet (i.e. containing vitamin D). Control mice were fed a normal diet throughout the experiment. The adult offspring underwent a comprehensive behavioural test battery at 10 weeks of age. We found that DVD-deficient mice of both strains exhibited significantly higher levels of exploration, as measured by the frequency of head dipping on the hole board test. In addition, DVD-deficient 129/SvJ mice, but not C57BL/6J mice, displayed spontaneous hyperlocomotion. There was no effect of maternal diet on parameters assessed by the SHIRPA primary screen, or on tests of sensorimotor gating, social behaviour, anxiety or depression. Some of these findings resemble the rat phenotype (hyperlocomotion) but there are also novel effects of DVD deficiency on mouse behaviour (increased exploration). This study confirms that the developmental absence of this vitamin affects brain function in another species (mouse), and lends further weight to the hypothesis that DVD deficiency in humans may contribute to adverse neuropsychiatric outcomes.
Keyword Locomotor activity
Hole board
Social interaction
Brain development
Mice
Vitamin D deficiency
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 30 Jul 2008, 02:18:40 EST