The human genome and the future of medicine

Mattick, John S. (2003) The human genome and the future of medicine. The Medical Journal of Australia, 179 4: 212-216.

Author Mattick, John S.
Title The human genome and the future of medicine
Journal name The Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2003-08-18
Sub-type Critical review of research, literature review, critical commentary
Volume 179
Issue 4
Start page 212
End page 216
Total pages 5
Editor R. J. A. Trent
R. Williamson
G. R. Sutherland
Place of publication Pyrmont, NSW, Australia
Publisher Australasian Medical Publishing Company
Language eng
Subject C1
11 Medical and Health Sciences
Formatted abstract
The draft human genome sequence (about 3 billion base pairs) was completed in 2001. Humans have fewer protein-coding genes than expected, and most of these are highly conserved among animals. Humans and other complex organisms produce massive amounts of non-coding RNAs, which may form another level of genetic output that controls differentiation and development. Aside from classical monogenic diseases and other differences caused by mutations and polymorphisms in protein-coding genes, much of the variation between individuals, including that which may affect our predispositions to common diseases, is probably due to differences in the non-coding regions of the genome (ie, the control architecture of the system). Within 10 years we can expect to see: increased penetration of DNA diagnostic tests to assess risk of disease, to diagnose pathogens, to determine the best treatment regimens, and for individual identification; a range of new pharmaceuticals as well as new gene and cell therapies to repair damage, to optimise health and to minimise future disease risk; and medicine become increasingly personalised, with the knowledge of individual genetic make-up and lifestyle influences.
Keyword Forecasting
Genome, human
Q-Index Code C1
Additional Notes Published as part of the series "The New Genetics".

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 11 Jun 2008, 02:11:23 EST