Antibody response in goats vaccinated with Liposome-adjuvated Clostridium perfringens Type D Epsilon toxoid

Uzal, F. A., Wong, J. P., Kelly, W. R. and Priest, J. (1999) Antibody response in goats vaccinated with Liposome-adjuvated Clostridium perfringens Type D Epsilon toxoid. Veterinary Research Communications, 23 3: 143-150. doi:10.1023/A:1006206216220


Author Uzal, F. A.
Wong, J. P.
Kelly, W. R.
Priest, J.
Title Antibody response in goats vaccinated with Liposome-adjuvated Clostridium perfringens Type D Epsilon toxoid
Journal name Veterinary Research Communications   Check publisher's open access policy
ISSN 0165-7380
Publication date 1999-01-01
Sub-type Article (original research)
DOI 10.1023/A:1006206216220
Open Access Status
Volume 23
Issue 3
Start page 143
End page 150
Total pages 8
Place of publication The Netherlands
Publisher Kluwer Academic Publishers
Language eng
Subject C1
300506 Pathology
780105 Biological sciences
Abstract A trial was performed using 20 goats to evaluate the antibody responses to a liposome-adjuvanted Clostridium perfringens epsilon toxoid vaccine (LIPV). The antibody response was compared with those produced by epsilon toxoid vaccines prepared using aluminium hydroxide (ALV) and incomplete Freud's adjuvant (FAV). The animals were allocated to four groups at the beginning of the trial. The animals in group 1 were vaccinated with ALV, while the animals in group 2 received FAV and those in groups 3 and 4 were vaccinated with LIPV. The animals in groups 1 to 3 received three doses of the corresponding vaccine at intervals of three weeks, while those in group 4 received only 1 dose of vaccine at the beginning of the trial. A blood sample was obtained from all the goats at the beginning of the trial and then weekly for 8 weeks. The samples were analysed for epsilon toxoid antibodies by an indirect ELISA technique. No major clinical abnormalities were observed in the animals after vaccination, with the exception of those that received the FAV, which experienced transient lameness. The highest antibody response was observed in the animals vaccinated with FAV, but they presented moderate to severe inflammatory tissue reactions at the injection site. Moderately high antibody responses were obtained with the ALV, with which only minor local reactions were observed. No significant antibody responses were obtained with the LIPV, nor were local reactions observed.
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Wed, 11 Jun 2008, 01:38:02 EST