Dietary fiber and the risk of colorectal cancer and adenoma in women

Fuchs, Charles S. , Giovannucci, Edward L. , Colditz, Graham A. , Hunter, David J. , Stampfer, Meir J. , Rosner, Bernard, Speizer, Frank E. and Willett, Walter C. (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine, 340 3: 169-176. doi:10.1056/NEJM199901213400301

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Author Fuchs, Charles S.
Giovannucci, Edward L.
Colditz, Graham A.
Hunter, David J.
Stampfer, Meir J.
Rosner, Bernard
Speizer, Frank E.
Willett, Walter C.
Title Dietary fiber and the risk of colorectal cancer and adenoma in women
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793
1533-4406
Publication date 1999-01-21
Sub-type Article (original research)
DOI 10.1056/NEJM199901213400301
Open Access Status File (Publisher version)
Volume 340
Issue 3
Start page 169
End page 176
Total pages 8
Place of publication Waltham, MA, United States
Publisher Massachusetts Medical Society
Collection year 1999
Language eng
Formatted abstract
Background: A high intake of dietary fiber has been thought to reduce the risk of colorectal cancer and adenoma.

Methods: We conducted a prospective study of 88,757 women, who were 34 to 59 years old and had no history of cancer, inflammatory bowel disease, or familial polyposis, who completed a dietary questionnaire in 1980. During a 16-year follow-up period, 787 cases of colorectal cancer were documented. In addition, 1012 patients with adenomas of the distal colon and rectum were found among 27,530 participants who underwent endoscopy during the follow-up period.

Results: After adjustment for age, established risk factors, and total energy intake, we found no association between the intake of dietary fiber and the risk of colorectal cancer; the relative risk for the highest as compared with the lowest quintile group with respect to fiber intake was 0.95 (95 percent confidence interval, 0.73 to 1.25). No protective effect of dietary fiber was observed when we omitted adjustment for total energy intake, when events during the first six years of follow-up were excluded, or when we excluded women who altered their fiber intake during the follow-up period. No significant association between fiber intake and the risk of colorectal adenoma was found.

Conclusions: Our data do not support the existence of an important protective effect of dietary fiber against colorectal cancer or adenoma.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 11 Jun 2008, 01:34:31 EST