The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides

Bourne, G. T., Meutermans, W. D. F. and Smythe, M. L. (1999) The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides. Tetrahedron Letters, 40 40: 7271-7274. doi:10.1016/S0040-4039(99)01473-2


Author Bourne, G. T.
Meutermans, W. D. F.
Smythe, M. L.
Title The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
Publication date 1999-01-01
Sub-type Article (original research)
DOI 10.1016/S0040-4039(99)01473-2
Volume 40
Issue 40
Start page 7271
End page 7274
Total pages 4
Place of publication UK
Publisher Elsevier Science Ltd
Language eng
Subject C1
780103 Chemical sciences
250302 Biological and Medical Chemistry
Abstract Herein, we report on the solid phase synthesis of a backbone amide linker. The key step is the acylation of a secondary amide in quantitative yield. To show the application of this methodology we synthesised linear peptides CCK (25-33) and ACP (64-73) using Boc-based protocols in high yields and purity. (C) 1999 Elsevier Science Ltd. All rights reserved.
Keyword Chemistry, Organic
Secondary Amine Acylation
Peptide Synthesis
Solid Support
Strategy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 11 Jun 2008, 01:29:10 EST