Single nucleotide polymorphisms in the equine transferrin gene

Brandon, Richard Bruce, Giffard, J. M. and Bell, Thomas Kevin (1999) Single nucleotide polymorphisms in the equine transferrin gene. Animal Genetics, 30 6: 439-443. doi:10.1046/j.1365-2052.1999.00546.x

Author Brandon, Richard Bruce
Giffard, J. M.
Bell, Thomas Kevin
Title Single nucleotide polymorphisms in the equine transferrin gene
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
Publication date 1999-12-01
Sub-type Article (original research)
DOI 10.1046/j.1365-2052.1999.00546.x
Open Access Status
Volume 30
Issue 6
Start page 439
End page 443
Total pages 5
Place of publication Oxford, U.K.
Publisher Blackwell Scientific Publications
Language eng
Subject C1
270200 Genetics
630107 Minor livestock (e.g. horses, goats, deer)
Formatted abstract
Single nucleotide polymorphisms (SNPs) in exons 13, 15 and 16 of equine transferrin for common, rare and mutant variants were investigated. Compared with previous work a further 13 SNPs have been identified, allowing for the two previously identified clades to be subdivided into 11 groups. A combination of one or more of eight SNPs can be used to classify the equine variants into these 11 groups, since most are co-inherited. Putative sites of glycosylation in exons 13 and 16 showed no polymorphism, suggesting that presence or absence of sugar moieties does not lead to electrophoretic variation between the variants. Using the 26 SNPs currently identified in transferrin it is still not possible to differentiate variants F1 from F2, or D from H2, which represent 75% of the variants occurring in Thoroughbred equine population. This suggests that further SNPs exist in equine transferrin. The significance of the high level of variation in exon 15 is discussed.
© 1999 International Society for Animal Genetics
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: QAAFI Biological Information Technology (QBIT) Publications
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Created: Wed, 11 Jun 2008, 01:19:52 EST