Sry and Sox9: Mammalian testis-determining genes

Koopman, P (1999) Sry and Sox9: Mammalian testis-determining genes. Cellular and Molecular Life Sciences, 55 6-7: 839-856. doi:10.1007/PL00013200

Author Koopman, P
Title Sry and Sox9: Mammalian testis-determining genes
Formatted title
Sry and Sox9: Mammalian testis-determining genes
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 1999-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/PL00013200
Open Access Status
Volume 55
Issue 6-7
Start page 839
End page 856
Total pages 18
Place of publication Basel, Switzerland
Publisher Birkhauser Verlag
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Formatted abstract
Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin. DNA bending appears to be part of the mechanism by which Sry influences transcription of genes downstream in a cascade of gene regulation leading to maleness, but the direct targets of Sry remain to be positively identified. One gene known to be downstream from Sry in this cascade is Sox9, which encodes a transcription factor related to Sry by the HMG box. Like Sry, mutations in Sox9 disrupt male development, but unlike Sry, the role of Sox9 is not limited to mammals. This review focuses on what is known about the two genes and their likely modes of action, and draws together recent data relating to how they might interconnect with the network of gene activity implicated in testis determination in mammals.
© Birkhäuser Verlag, Basel, 1999
Keyword Biochemistry & Molecular Biology
Cell Biology
Sex Determination
Sox Genes
Autosomal Sex Reversal
Mullerian-inhibiting Substance
Xy Gonadal-dysgenesis
Adrenal Hypoplasia Congenita
Dna-binding Properties
Nuclear Receptor Sf-1
Ii Collagen Gene
Campomelic Dysplasia
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 119 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 11 Jun 2008, 01:09:21 EST