NTS catecholamine cell recruitment by hemorrhage and hypoxia

Buller, K. M., Smith, D. W. and Day, T. A. (1999) NTS catecholamine cell recruitment by hemorrhage and hypoxia. NeuroReport, 10 18: 3853-3856. doi:10.1097/00001756-199912160-00024


Author Buller, K. M.
Smith, D. W.
Day, T. A.
Title NTS catecholamine cell recruitment by hemorrhage and hypoxia
Journal name NeuroReport   Check publisher's open access policy
ISSN 0959-4965
Publication date 1999-01-01
Sub-type Article (original research)
DOI 10.1097/00001756-199912160-00024
Open Access Status
Volume 10
Issue 18
Start page 3853
End page 3856
Total pages 4
Editor K. Buller
D. Smith
T. Day
Place of publication Oxford, UK
Publisher Lippincott, Williams & Wilkins
Language eng
Subject C1
320700 Neurosciences
730104 Nervous system and disorders
Abstract IMMUNOLABELLING for Fos and tyrosine hydroxylase was used to determine the patterns of activation of nucleus tractus solitarius catecholamine cells in response to graded levels of hemorrhage (0, 4, 8, 12 and 16 ml/kg) and systemic hypoxia (21, 14, 12, 10 and 8% O-2) in conscious rats. Both stimuli elicited graded catecholamine cell recruitment with thresholds of 8 ml/kg and 12% O-2. The majority of responsive neurons were A2 noradrenergic rather than C2 adrenergic cells. After hemorrhage most Fos-positive catecholamine cells were found below obex whereas most hypoxia-responsive cells were rostral to obex. These distinctive patterns of catecholamine cell recruitment may explain the differences in neuroendocrine responses to these stimuli. (C) 1999 Lippincott Williams & Wilkins.
Keyword Neurosciences
A2 Noradrenergic Cells
C2 Adrenergic Cells
Catecholamine Cells
Hemorrhage
Nucleus Tractus Solitarius
Systemic Hypoxia
Brain-stem Projections
C-fos Protein
Rat-brain
Paraventricular Nucleus
Electrical-stimulation
Vasopressin Neurons
Solitary Tract
Expression
Medulla
Nerve
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 11 Jun 2008, 01:03:43 EST