Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects

Meeking, D. R., Wallace, J., Cuneo, R. C. and Russell-Jones, D. L. (1999) Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. European Journal of Endocrinology, 141 1: 22-26. doi:10.1530/eje.0.1410022


Author Meeking, D. R.
Wallace, J.
Cuneo, R. C.
Russell-Jones, D. L.
Title Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects
Journal name European Journal of Endocrinology   Check publisher's open access policy
ISSN 0804-4643
Publication date 1999-07-01
Sub-type Article (original research)
DOI 10.1530/eje.0.1410022
Open Access Status Not yet assessed
Volume 141
Issue 1
Start page 22
End page 26
Total pages 5
Place of publication Norway
Publisher Scandinavian Univ. Press
Language eng
Subject C1
730105 Endocrine organs and diseases (incl. diabetes)
321004 Endocrinology
Abstract There is evidence that melatonin may play a role in modulating pituitary secretion, although the mechanisms are unclear.We examined the effects of a single dose of oral melatonin (5 mg) on exerciseinduced GH secretion. In a randomised, double-blind, placebo-controlled study, seven healthy male subjects undertook an initial period of graded bicycle ergometric exercise to determine maximum workload and oxygen uptake (VO2 max). Subjects were subsequently studied on two further occasions, receiving either melatonin or placebo in random order at the onset of each study (¹60 min). At 0 min a period of bicycle exercise was performed for 8 min at a workload corresponding to 70% of that achieved at VO2 max. Serum GH and IGF-binding protein-1 (IGFBP-1) concentration was measured at 15-min intervals from the onset of the study until 120 min post-exercise. Blood was also sampled for the measurement of plasma glucose, insulin, non-esterified fatty acids, IGFBP-3, melatonin and vasopressin concentration. There was an exercise-induced increase in GH concentration following melatonin which was greater compared with placebo as assessed by both area under the curve (P <0.01) and peak increase in GH levels (P< 0.01). The peak increase in IGFBP-1 levels post-exercise was also significantly greater following melatonin compared with placebo (P< 0.01) but did not quite reach levels of significance as measured by area under the curve (P= 0.07). Since exercise-induced GH secretion is thought to be mediated predominantly through a hypothalamic pathway, it seems likely that melatonin facilitates GH secretion at a hypothalamic level
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 11 Jun 2008, 00:54:09 EST