Increased nitric oxide synthase in the vasculature of the epaulette shark brain following hypoxia

C. Renshaw, Gillian M. and Dyson, Susan E. (1999) Increased nitric oxide synthase in the vasculature of the epaulette shark brain following hypoxia. NeuroReport, 10 8: 1707-1712.

Author C. Renshaw, Gillian M.
Dyson, Susan E.
Title Increased nitric oxide synthase in the vasculature of the epaulette shark brain following hypoxia
Journal name NeuroReport   Check publisher's open access policy
ISSN 0959-4965
Publication date 1999-01-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 10
Issue 8
Start page 1707
End page 1712
Total pages 6
Place of publication Philadelphia, USA
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
270604 Comparative Physiology
780105 Biological sciences
Abstract EPAULETTE sharks inhabiting reef platforms are exposed to hypoxic and hyperoxic cycles. The adaptive mechanisms used to prevent neurological damage during these cycles have not been examined. Nitric oxide has a neuroprotective role in some hypoxia-tolerant species. We examined epaulette brains following a severe experimental hypoxic regimen (0.39 mgO(2)/l for 2 h) and compared nitric oxide synthase (NOS) expression with that in normoxic controls using NADPH-diaphorase staining. Intense NOS activity occurred in microvasculature following exposure to a severely hypoxic environment in contrast to the low levels seen in controls. We established for the first time that the epaulette shark was hypoxia-tolerant because there was no delayed phase of neuronal apoptosis. Enhanced NOS production in response to hypoxia may cause vasodilation, which would maintain the appropriate metabolic environment for continued neuronal survival during exposure to hypoxia. NeuroReport 10:1707-1712 (C) 1999 Lippincott Williams & Wilkins.
Keyword Neurosciences
Apoptosis
Endothelial
Histology
Hypoxia
Tolerance
Nadph-diaphorase
Nervous System
Nitric Oxide
Perivascular
Vasodilation
Cerebral Blood-flow
Anoxia
Turtles
Fish
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Wed, 11 Jun 2008, 00:48:01 EST