The actions of bacterial DNA on murine macrophages

Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999) The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 4: 542-548.

Author Sester, D. P.
Stacey, K. J.
Sweet, M. J.
Beasley, S. J.
Cronau, S. L.
Hume, D. A.
Title The actions of bacterial DNA on murine macrophages
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
Publication date 1999-01-01
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not yet assessed
Volume 66
Issue 4
Start page 542
End page 548
Total pages 7
Place of publication Bethesda, Maryland
Publisher Federation of American Society of Experimental Biology
Language eng
Subject C1
270102 Cell Metabolism
780105 Biological sciences
Abstract Murine macrophages are able to distinguish bacterial from mammalian DNA. The response is mimicked by single-stranded oligonucleotides containing unmethylated CG dinucleotides (CpG motifs) in specific sequence contests. The dose-response curve for activation is influenced by variation in the sequence Banking the core CpG motif. CpG or bacterial DNA activates several signaling pathways in common with bacterial lipopolysaccharide (LPS), leading to induction of cytokine genes such as tumor necrosis factor or, Pretreatment with LPS causes desensitization to subsequent activation by CpG DNA. Both stimuli also cause cell cycle arrest in macrophages proliferating in response to the macrophage growth factor colony-stimulating factor-1 (CSF-1), but prevent apoptosis caused by growth factor removal, In part, cell cycle arrest by CpG DNA and LPS may be linked to rapid down-modulation of the CSF-1 receptor from the cell surface, a response that occurs iu an all-or-nothing manner. The response of macrophages to CpG DNA has aspects in common with the DNA damage response in other cell types, which may provide clues to the underlying mechanism.
Keyword Cell Biology
Hematology
Immunology
Cpg Motifs
Colon-stimulating Factor-1
Lipopolysaccharide
Colony-stimulating Factor
Immunostimulatory Dna
Factor-i
Th1 Responses
Cutting Edge
Factor Csf-1
Hiv-1 Ltr
B-cell
C-fms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 11 Jun 2008, 00:47:48 EST