DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

Iino, H., Jass, J. R., Simms, L. A., Young, J., Leggett, B., Ajioka, Y. and Watanabe, H. (1999) DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?. Journal of Clinical Pathology, 52 1: 5-9.

Author Iino, H.
Jass, J. R.
Simms, L. A.
Young, J.
Leggett, B.
Ajioka, Y.
Watanabe, H.
Title DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?
Journal name Journal of Clinical Pathology   Check publisher's open access policy
ISSN 0021-9746
Publication date 1999-01-01
Sub-type Article (original research)
Volume 52
Issue 1
Start page 5
End page 9
Total pages 5
Place of publication London
Publisher BMJ Publishing Group
Language eng
Subject C1
730108 Cancer and related disorders
321020 Pathology
Abstract Aim-To investigate the distribution of DNA microsatellite instability (MSI) in a series of hyperplastic polyps, serrated adenomas, and mixed polyps of the colorectum. Methods-DNA was extracted from samples of 73 colorectal polyps comprising tubular adenomas (23), hyperplastic polyps (21), serrated adenomas (17), and mixed polyps (12). The presence of MSI was investigated at six loci: MYCL, D2S123, F13B, BAT-40, BAT-26, and c-myb T22, using polymerase chain reaction based methodology. MSI cases were classified as MSI-Low (MSI-L) and MSI-High (MSI-H), based on the number of affected loci. Results-The frequency of MSI increased in tubular adenomas (13%), hyperplastic polyps (29%), serrated adenomas (53%), and mixed polyps (83%) (Wilcoxon rank sum statistic, p < 0.001). Hyperplastic epithelium was present in nine of 12 mixed polyps and showed MSI in eight of these. MSI was mostly MSI-L. MSI-H occurred in two serrated adenomas and three mixed polyps. Clonal relations were demonstrated between hyperplastic and dysplastic epithelium in four of eight informative mixed polyps. Conclusions-The findings support the view that hyperplastic polyps may be fundamentally neoplastic rather than hyperplastic. A proportion of hyperplastic polyps may serve as a precursor of a subset (10%) of colorectal cancers showing the MSI-L phenotype, albeit through the intermediate step of serrated dysplasia. This represents a novel and distinct morphogenetic pathway for colorectal cancer.
Keyword Pathology
Polyp
Colorectum
Microsatellite Instability
Serrated Adenoma
Nonpolyposis Colon-cancer
Replication Errors
Mutations
Tumors
Deletion
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 188 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 10 Jun 2008, 23:41:35 EST