Kinetics of absorption atelectasis during anesthesia: A mathematical model

Joyce, C. J. and Williams, A. B. (1999) Kinetics of absorption atelectasis during anesthesia: A mathematical model. Journal of Applied Physiology, 86 4: 1116-1125.

Author Joyce, C. J.
Williams, A. B.
Title Kinetics of absorption atelectasis during anesthesia: A mathematical model
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 1999-04-01
Sub-type Article (original research)
Volume 86
Issue 4
Start page 1116
End page 1125
Total pages 10
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Language eng
Subject C1
321001 Anaesthesiology
730110 Respiratory system and diseases (incl. asthma)
Formatted abstract
Recent computed tomography studies show that inspired gas composition affects the development of anesthesia-related atelectasis. This suggests that gas absorption plays an important role in the genesis of the atelectasis. A mathematical model was developed that combined models of gas exchange from an ideal lung compartment, peripheral gas exchange, and gas uptake from a closed collapsible cavity. It was assumed that, initially, the lung functioned as an ideal lung compartment but that, with induction of anesthesia, the airways to dependent areas of lung closed and these areas of lung behaved as a closed collapsible cavity. The main parameter of interest was the time the unventilated area of lung took to collapse; the effects of preoxygenation and of different inspired gas mixtures during anesthesia were examined. Preoxygenation increased the rate of gas uptake from the unventilated area of lung and was the most important determinant of the time to collapse. Increasing the inspired O2 fraction during anesthesia reduced the time to collapse. Which inert gas (N2 or N2O) was breathed during anesthesia had minimal effect on the time to collapse.
Copyright © 1999 the American Physiological Society
Keyword Physiology
Sport Sciences
Nitrogen Splinting
Nitrous Oxide
Pulmonary Collapse
Perioperative Atelectasis
Gas-exchange Impairment
Muscle Paralysis
Q-Index Code C1
Additional Notes Published under "Gas Exchange, Mechanics, And Airways".

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 10 Jun 2008, 23:27:01 EST